Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats.

ABSTRACT:

Background

Circadian rhythms play an essential role in physiological function. The molecular clock that underlies circadian physiological function consists of a core group of transcription factors, including the protein PER1 (Period1). Studies in mice show that PER1 plays a role in the regulation of blood pressure and renal sodium handling; however, the results are dependent on the strain being studied. Using male Dahl salt-sensitive (SS) rats with global knockout of PER1 (SS^Per1-/-), we aim to test the hypothesis that PER1 plays a key role in the regulation of salt-sensitive blood pressure.

Methods

The model was generated using CRISPR/Cas9 and was characterized using radiotelemetry and measures of renal function and circadian rhythm.

Results

SS^Per1-/-

SUBMITTER: Zietara A 

PROVIDER: S-EPMC9669134 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature