Principles Governing the Phase Separation of Multidomain Proteins.

ABSTRACT: A variety of membraneless organelles, often termed "biological condensates", play an important role in the regulation of cellular processes such as gene transcription, translation, and protein quality control. On the basis of experimental and theoretical investigations, liquid-liquid phase separation (LLPS) has been proposed as a possible mechanism for the origin of biological condensates. LLPS requires multivalent macromolecules that template the formation of long-range, intermolecular interaction networks and results in the formation of condensates with defined composition and material properties. Multivalent interactions driving LLPS exhibit a wide range of modes from highly stereospecific to nonspecific and involve both folded and disordered regions. Multidomain proteins serve as suita

SUBMITTER: Mohanty P 

PROVIDER: S-EPMC9669140 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature