Serotonin Transporter Imaging in Multiple System Atrophy and Parkinson's Disease.

ABSTRACT:

Background

Both Parkinson's disease (PD) and multiple system atrophy (MSA) exhibit degeneration of brainstem serotoninergic nuclei, affecting multiple subcortical and cortical serotoninergic projections. In MSA, medullary serotoninergic neuron pathology is well documented, but serotonin system changes throughout the rest of the brain are less well characterized.

Objectives

To use serotonin transporter [¹¹ C]3-amino-4-(2-dimethylaminomethyl-phenylsulfaryl)-benzonitrile positron emission tomography (PET) to compare serotoninergic innervation in patients with MSA and PD.

Methods

We performed serotonin transporter PET imaging in 18 patients with MSA, 23 patients with PD, and 16 healthy controls to explore differences in brainstem, subcortical, and cortical regi

SUBMITTER: Chou KL 

PROVIDER: S-EPMC9669145 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature