Malnutrition and immune cell subsets in children undergoing kidney transplantation.

ABSTRACT:

Background

Malnutrition, including obesity and undernutrition, among children is increasing in prevalence and is common among children on renal replacement therapy. The effect of malnutrition on the pre-transplant immune system and how the pediatric immune system responds to the insult of both immunosuppression and allotransplantation is unknown. We examined the relationship of nutritional status with post-transplant outcomes and characterized the peripheral immune cell phenotypes of children from the Immune Development of Pediatric Transplant (IMPACT) study.

Methods

Ninety-eight patients from the IMPACT study were classified as having obesity, undernutrition, or normal nutrition-based pre-transplant measurements. Incidence of infectious and alloimmune outcomes at 1-year pos

SUBMITTER: Shaw BI 

PROVIDER: S-EPMC9669171 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature