SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes.

ABSTRACT:

Background

Heart failure with preserved ejection fraction (HFpEF) is a growing health problem without effective therapies. Epidemiological studies indicate that diabetes is a strong risk factor for HFpEF, and about 45% of patients with HFpEF are suffering from diabetes, yet the underlying mechanisms remain elusive.

Methods

Using a combination of echocardiography, hemodynamics, RNA-sequencing, molecular biology, in vitro and in vivo approaches, we investigated the roles of SIRT6 (sirtuin 6) in regulation of endothelial fatty acid (FA) transport and HFpEF in diabetes.

Results

We first observed that endothelial SIRT6 expression was markedly diminished in cardiac tissues from heart failure patients with diabetes. We then established an experimental mouse model of HFpEF in

SUBMITTER: Wu X 

PROVIDER: S-EPMC9669223 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature