Ontology highlight
ABSTRACT:
SUBMITTER: Lu D
PROVIDER: S-EPMC9669245 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Lu Dong D Yu Xin X Lin Hanfeng H Cheng Ran R Monroy Erika Y EY Qi Xiaoli X Wang Meng C MC Wang Jin J
Chemical Society reviews 20221114 22
Proteolysis-targeting chimeras (PROTACs) and targeted covalent inhibitors (TCIs) are currently two exciting strategies in the fields of chemical biology and drug discovery. Extensive research in these two fields has been conducted, and significant progress in these fields has resulted in many clinical candidates, some of which have been approved by FDA. Recently, a novel concept termed covalent PROTACs that combine these two strategies has emerged and gained an increasing interest in the past se ...[more]