Sleeve gastrectomy attenuated diabetes-related cognitive decline in diabetic rats.

ABSTRACT:

Objective

To investigate the effects of sleeve gastrectomy (SG) on diabetes-related cognitive decline (DCD) in rats with diabetic mellitus (DM).

Methods and methods

Forty Wistar rats were randomly divided into control (CON) group (n=10), diabetes mellitus (DM) group (n=10), sham operation (SHAM) group (n=10) and SG group (n=10). DM model was established by high-fat diet (HFD) combined with intraperitoneal injection of streptozocin (STZ). Behavioral evaluation was given using Morris water maze test and Y-maze. In addition, PET-CT, TUNEL assay, histological analysis, transmission electron microscopy (TEM), immunohistochemistry (IHC) and Western blot analysis were used to evaluate the alleviating effects and potential mechanisms of SG on DCD in DM rats.

Results

Compared

SUBMITTER: Ding H 

PROVIDER: S-EPMC9669300 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature