Complete genome analysis reveals evolutionary history and temporal dynamics of Marek's disease virus.

ABSTRACT: Marek's disease has caused enormous losses in poultry production worldwide. However, the evolutionary process and molecular mechanisms underlying Marek's disease virus (MDV) remain largely unknown. Using complete genomic sequences spanning an unprecedented diversity of MDVs, we explored the evolutionary history and major patterns in viruses sampled from 1964 to 2018. We found that the evolution of MDV strains had obvious geographical features, with the Eurasian and North American strains having independent evolutionary paths, especially for Asian strains. The evolution of MDVs generally followed a clock-like structure with a relatively high evolutionary rate. Asian strains had evolved at a faster rate than European strains, with most genetic mutations occurring in Asian strains. Our result

SUBMITTER: Li K 

PROVIDER: S-EPMC9669313 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature