Efficacy and safety of brigatinib in ALK-positive non-small cell lung cancer treatment: A systematic review and meta-analysis.

ABSTRACT:

Background

Brigatinib is a central nervous system-active second-generation anaplastic lymphoma kinase (ALK) inhibitor that targets a broad range of ALK rearrangements in patients with non-small cell lung cancer (NSCLC). The current study aimed to analyze the pooled effects and adverse events of brigatinib in patients with ALK-positive NSCLC.

Methods

The pooled estimates and 95% confidence intervals (CI) were calculated with DerSimonian-Laird method and the random effect model.

Results

The pooled objective response rate (ORR) and disease control rate (DCR) of brigatinib were 64% (95% CI 45%-83%) and 88% (95% CI 80%-96%), respectively. The pooled mPFS was 10.52 months (95% CI 7.66-13.37). In the subgroup analyses by treatment line, the highest mPFS was rea

SUBMITTER: Xing P 

PROVIDER: S-EPMC9669367 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature