Ontology highlight
ABSTRACT:
SUBMITTER: Lai X
PROVIDER: S-EPMC9669405 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Lai Xinyuan X Li Chuanyun C Xiang Chengang C Pan Zihang Z Zhang Kai K Wang Lei L Xie Bingqing B Cao Junning J Shi Jihang J Deng Juan J Lu Shichun S Deng Hongkui H Zhuang Hui H Li Tong T Shi Yan Y Xiang Kuanhui K
Stem cell reports 20221020 11
The detailed understanding of fibrogenesis has been hampered by a lack of important functional quiescence characteristics and an in vitro model to recapitulate hepatic stellate cell (HSC) activation. In our study, we establish robust endoderm- and mesoderm-sourced quiescent-like induced HSCs (iHSCs) derived from human pluripotent stem cells. Notably, iHSCs present features of mature HSCs, including accumulation of vitamin A in the lipid droplets and maintained quiescent features. In addition, iH ...[more]