Ontology highlight
ABSTRACT:
SUBMITTER: Therachiyil L
PROVIDER: S-EPMC9669513 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Therachiyil Lubna L Anand Anjana A Azmi Abdullah A Bhat Ajaz A Korashy Hesham M HM Uddin Shahab S
F1000Research 20221104
The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, <i>RAS</i>, especially <i>KRAS</i> mutational status at codons 12, 13, and 61, ranges from 6-65% spanning different histo-types. Normally RAS regulates several signaling pathways involved in a myriad of cellular signaling cascades mediating numerous cellular processes like cell proliferation, differentiation, invasion, and death. Aberrant ...[more]