Importance of beta cell mass for glycaemic control in people with type 1 diabetes.

ABSTRACT:

Aims/hypothesis

The role of beta cell mass in the balance of glucose control and hypoglycaemic burden in people with type 1 diabetes is unclear. We applied positron emission tomography (PET) imaging with radiolabelled exendin to compare beta cell mass among people with type 1 diabetes and either low glucose variability (LGV) or high glucose variability (HGV).

Methods

All participants with either LGV (n=9) or HGV (n=7) underwent a mixed-meal tolerance test to determine beta cell function and wore a blinded continuous glucose monitor for a week. After an i.v. injection with [⁶⁸Ga]Ga-NODAGA-exendin-4, PET images were acquired for the quantification of pancreatic uptake of radiolabelled exendin. The mean standardised uptake value (SUVmean) of the pancreas was used to

SUBMITTER: Jansen TJP 

PROVIDER: S-EPMC9669532 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature