¹⁹F MRI-fluorescence imaging dual-modal cell tracking with partially fluorinated nanoemulsions.

ABSTRACT: As a noninvasive "hot-spot" imaging technology, fluorine-19 magnetic resonance imaging (¹⁹F MRI) has been extensively used in cell tracking. However, the peculiar physicochemical properties of perfluorocarbons (PFCs), the most commonly used ¹⁹F MRI agents, sometimes cause low sensitivity, poor cell uptake, and misleading results. In this study, a partially fluorinated agent, perfluoro-tert-butyl benzyl ether, was used to formulate a ¹⁹F MRI-fluorescence imaging (FLI) dual-modal nanoemulsion for cell tracking. Compared with PFCs, the partially fluorinated agent showed considerably improved physicochemical properties, such as lower density, shorter longitudinal relaxation times, and higher solubility to fluorophores, while maintaining high ¹⁹

SUBMITTER: Tang T 

PROVIDER: S-EPMC9669590 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature