Effect of Inactivation of Mst1 and Mst2 in the Mouse Adrenal Cortex.

ABSTRACT: Recent conditional knockout of core components of the Hippo signaling pathway in the adrenal gland of mice has demonstrated that this pathway must be tightly regulated to ensure proper development and maintenance of the adrenal cortex. We report herein that the most upstream kinases of the pathway, the mammalian STE20-like protein kinases 1 and 2 (MST1and MST2, respectively), are expressed in the mouse adrenal cortex with MST2 expression being restricted to the zona glomerulosa (zG). To further explore the role of Hippo signaling in adrenocortical cells, we conditionally deleted Mst1/2 in steroidogenic cells using an Nr5a1-cre strain (Mst1 ^flox/flox ; Mst2 ^flox/flox ; Nr5a1-cre). Our results show that the loss of MST1/2 leads to the prematu

SUBMITTER: Abou Nader N 

PROVIDER: S-EPMC9669781 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature