Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies.

ABSTRACT:

Purpose

The purpose of this study was to determine whether rodent lacrimal glands (LGs) represent a suitable surrogate for human tissue in bio-engineering research, we undertook a meticulous histological and histochemical comparison of these two tissues.

Methods

Histological techniques and immunohistochemistry were used to compare the structure of adult human and rat LG tissues and the expression of key functional tissue elements.

Results

Compared with humans, the rat LG is comprised of much more densely packed acini which are devoid of an obvious central lumen. Myoepithelial, fibroblasts, dendritic cells, T cells, and putative progenitor cells are present in both tissues. However, human LG is replete with epithelium expressing cytokeratins 8 and 18, whereas rat LG ep

SUBMITTER: Wood JPM 

PROVIDER: S-EPMC9669807 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature