Unknown

Dataset Information

0

Role of adherent invasive Escherichia coli in pathogenesis of inflammatory bowel disease.


ABSTRACT: Gut microbiota imbalances play an important role in inflammatory bowel disease (IBD), but no single pathogenic microorganism critical to IBD that is specific to the IBD terminal ileum mucosa or can invade intestinal epithelial cells has been found. Invasive Escherichia coli (E. coli) adhesion to macrophages is considered to be closely related to the pathogenesis of inflammatory bowel disease. Further study of the specific biological characteristics of adherent invasive E. coli (AIEC) may contribute to a further understanding of IBD pathogenesis. This review explores the relationship between AIEC and the intestinal immune system, discusses the prevalence and relevance of AIEC in Crohn's disease and ulcerative colitis patients, and describes the relationship between AIEC and the disease site, activity, and postoperative recurrence. Finally, we highlight potential therapeutic strategies to attenuate AIEC colonization in the intestinal mucosa, including the use of phage therapy, antibiotics, and anti-adhesion molecules. These strategies may open up new avenues for the prevention and treatment of IBD in the future.

SUBMITTER: Zheng L 

PROVIDER: S-EPMC9669839 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Role of adherent invasive <i>Escherichia coli</i> in pathogenesis of inflammatory bowel disease.

Zheng Lie L   Duan Sheng-Lei SL   Dai Yan-Cheng YC   Wu Shi-Cheng SC  

World journal of clinical cases 20221101 32


Gut microbiota imbalances play an important role in inflammatory bowel disease (IBD), but no single pathogenic microorganism critical to IBD that is specific to the IBD terminal ileum mucosa or can invade intestinal epithelial cells has been found. Invasive <i>Escherichia coli</i> (<i>E. coli)</i> adhesion to macrophages is considered to be closely related to the pathogenesis of inflammatory bowel disease. Further study of the specific biological characteristics of adherent invasive <i>E. coli</  ...[more]

Similar Datasets

| S-EPMC6488085 | biostudies-literature
| S-EPMC8273539 | biostudies-literature
| S-EPMC4820460 | biostudies-literature
| S-EPMC5964128 | biostudies-literature
| S-EPMC3554634 | biostudies-literature
| S-EPMC8678049 | biostudies-literature
| S-EPMC6357120 | biostudies-literature
| S-EPMC6557746 | biostudies-literature
| S-EPMC3995253 | biostudies-literature
| S-EPMC7034058 | biostudies-literature