Dataset Information

Impaired neuronal integrity in traumatic brain injury detected by ¹²³I-iomazenil single photon emission computed tomography and MRI.

ABSTRACT: This study was aiming at investigating the extent of neuronal damage in cases of traumatic brain injury (TBI) with diffuse axonal injury (DAI) using ¹²³I-iomazenil(IMZ) SPECT and MRI. We compared the findings in 31 patients with TBI without any major focal brain lesions and 25 age-matched normal controls. Subjects underwent ¹²³I-IMZ SPECT and MRI, and also assessment by cognitive function tests. The partial volume effect of ¹²³I-IMZ SPECT was corrected using MRI. In the patients with TBI, decreased spatial concentration of ¹²³I-IMZ binding was detected in the medial frontal/orbitofrontal cortex, posterior cingulate gyrus, cuneus, precuneus, and superior region of the cerebellum. ROC analysis of ¹²³I-IMZ SPECT for the detection of neuronal injury showed a high diagnostic ability of ¹²³I-IMZ binding density for TBI in these areas. The decreased ¹²³I-IMZ uptake density in the cuneus and precuneus was associated with cognitive decline after the injury. In the patients with TBI, brain atrophy was detected in the frontal lobe, anterior temporal and parietal cortex, corpus callosum, and posterior part of the cerebellum. Evaluation of the neuronal integrity by ¹²³I-IMZ SPECT and MRI provides important information for the diagnosis and pathological interpretation in cases of TBI with DAI.

SUBMITTER: Kato H

PROVIDER: S-EPMC9670011 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Impaired neuronal integrity in traumatic brain injury detected by 123I-iomazenil single photon emission computed tomography and MRI.

Kato Hiroki H Nakagawara Jyoji J Hachisuka Kenji K Hatazawa Jun J Ikoma Katsunori K Suehiro Eiichi E Iida Hidehiko H Ogasawara Kuniaki K Iizuka Osamu O Ishiai Sumio S Ichikawa Tadashi T Nariai Tadashi T Okazaki Tetsuya T Shiga Tohru T Mori Etsuro E

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20220707 12

This study was aiming at investigating the extent of neuronal damage in cases of traumatic brain injury (TBI) with diffuse axonal injury (DAI) using 123I-iomazenil(IMZ) SPECT and MRI. We compared the findings in 31 patients with TBI without any major focal brain lesions and 25 age-matched normal controls. Subjects underwent 123I-IMZ SPECT and MRI, and also assessment by cognitive function tests. The partial volume effect of 123I-IMZ SPECT was corrected using MRI. ...[more]

PMID: 35796498

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Project description:We present the attenuated spline reconstruction technique (aSRT) which provides an innovative algorithm for single photon emission computed tomography (SPECT) image reconstruction. aSRT is based on an analytic formula of the inverse attenuated Radon transform. It involves the computation of the Hilbert transforms of the linear attenuation function and of two sinusoidal functions of the so-called attenuated sinogram These computations are achieved by employing the attenuation information provided by computed tomography (CT) scans and by utilizing custom-made cubic spline interpolation. The purpose of this work is: (i) to present the mathematics of aSRT, (ii) to reconstruct simulated and real SPECT/CT data using aSRT and (iii) to evaluate aSRT by comparing it to filtered backprojection (FBP) and to ordered subsets expectation minimization (OSEM) reconstruction algorithms. Simulation studies were performed by using an image quality phantom and an appropriate attenuation map. Reconstructed images were generated for 45, 90 and 180 views over 360 degrees with 20 realizations and involved Poisson noise of three different levels (NL), namely 100% (NL1), 50% (NL2) and 10% (NL3) of the total counts, respectively. Moreover, real attenuated SPECT sinograms were reconstructed from a real study of a Jaszczak phantom, as well as from a real clinical myocardial SPECT/CT study. Comparisons between aSRT, FBP and OSEM reconstructions were performed using contrast, bias and image roughness. The results suggest that aSRT can efficiently produce accurate attenuation-corrected reconstructions for simulated and real phantoms, as well as for clinical data. In particular, in the case of the clinical myocardial study, aSRT produced reconstructions with higher cold contrast than both FBP and OSEM. aSRT, by incorporating the attenuation correction within itself, may provide an improved alternative to FBP. This is particularly promising for 'cold' regions as those occurring in myocardial ischaemia.

Dataset Information

Impaired neuronal integrity in traumatic brain injury detected by ¹²³I-iomazenil single photon emission computed tomography and MRI.

Publications

Impaired neuronal integrity in traumatic brain injury detected by <sup>123</sup>I-iomazenil single photon emission computed tomography and MRI.

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