Dataset Information

The oral bioaccessibility and gingival cytotoxicity of metal(loid)s in wild vegetables from mining areas: Implication for human oral health.

ABSTRACT:

Background

Heavy metal(loid)s are frequently detected in vegetables posing potential human health risks, especially for those grown around mining areas. However, the oral bioaccessibility and gingival cytotoxicity of heavy metals in wild vegetables remain unclear.

Methods

In this study, we assessed the total and bioaccessible Cr, As, Cd, Pb, and Ni in four wild vegetables from mining areas in Southwest China. In addition, the cytotoxicity and underlying mechanisms of vegetable saliva extracts on human gingival epithelial cells (HGEC) were studied.

Results

The Plantago asiatica L. (PAL) showed the highest bioaccessible Cr, As, Cd, and Pb, while the greatest bioaccessible Ni was in Taraxacum mongolicum (TMM). The Pteridium aquilinum (PAM), Chenopodium album L. (CAL), and TMM extracts decreased cell viability, induced apoptosis, caused DNA damage, and disrupted associated gene expressions. However, PAL extracts which have the highest bioaccessible heavy metals did not present adverse effects on HGEC, which may be due to its inhibition of apoptosis by upregulating p53 and Bcl-2.

Conclusion

Our results indicated that polluted vegetable intake caused toxic effects on human gingiva. The heavy metals in vegetables were not positively related to human health risks. Collectively, both bioaccessibility and toxic data should be considered for accurate risk assessment.

SUBMITTER: Tian W

PROVIDER: S-EPMC9670124 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

The oral bioaccessibility and gingival cytotoxicity of metal(loid)s in wild vegetables from mining areas: Implication for human oral health.

Tian Wen W Gao Peng P Zong Da-Peng DP Liu Jian-Jun JJ Zhang Meng-Yan MY Wang Cheng-Chen CC Wang Zhen-Xing ZX Wang Jian-Min JM Niu You-Ya YY Xiang Ping P

Frontiers in nutrition 20221104

<h4>Background</h4>Heavy metal(loid)s are frequently detected in vegetables posing potential human health risks, especially for those grown around mining areas. However, the oral bioaccessibility and gingival cytotoxicity of heavy metals in wild vegetables remain unclear.<h4>Methods</h4>In this study, we assessed the total and bioaccessible Cr, As, Cd, Pb, and Ni in four wild vegetables from mining areas in Southwest China. In addition, the cytotoxicity and underlying mechanisms of vegetable sal ...[more]

PMID: 36407553

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Project description:Traffic activities release large amounts of trace metal(loid)s in urban environments. However, the impact of vehicle operation-associated emissions on trace metal(loid) enrichment in road dust and the potential migration of these trace metal(loid)s to the surrounding environment remain unclear. We evaluated the contamination, sequential fraction, and bioaccessibility of trace metal(loid)s in urban environments by assessing their presence in road dust, garden vegetables, and tree tissues, including bark and aerial roots, at a traffic-training venue impacted by vehicle operation emissions and, finally, calculated the bioaccessibility-based health risk. The results indicated a significant accumulation of trace metal(loid)s in road dust, with the highest lead (Pb), cadmium (Cd), and antimony (Sb) concentrations in the garage entrance area due to higher vehicle volumes, frequent vehicle starts and stops, and lower speeds. Aerial roots exposed to hill start conditions exhibited the highest Pb, Zn, and Sb levels, potentially caused by high road dust resuspension, confirming that this tree tissue is an appropriate bioindicator. Sequential extraction revealed high percentages of carbonate-, Fe/Mn oxide-, and organic/sulphide-associated fractions of Pb, copper (Cu), and zinc (Zn) in road dust, while most Cd, Cr, Ni, and Sb occurred as residual fractions. According to the potential mobilizable fractions in sequential extraction, the in vitro gastrointestinal method could be more suitable than the physiologically based extraction test to evaluate the bioaccessibility-related risk of traffic-impacted road dust. The bioaccessibility-based health risk assessment of the road dust or soil confirmed no concern about noncarcinogenic risk, while the major risk originated from Pb although leaded gasoline was prohibited before the venue establishment. Furthermore, the cancer risks (CRs) analysis showed the probable occurrence of carcinogenic health effects from Cd and Ni to adults and from Cd, Cr, and Ni to children. Furthermore, the Cd and Pb concentrations in the edible leaves of cabbage and radish growing in gardens were higher than the recommended maximum value. This study focused on the health risks of road dust directly impacted by vehicle emissions and provides accurate predictions of trace metal(loid) contamination sources in the urban environment.

Dataset Information

The oral bioaccessibility and gingival cytotoxicity of metal(loid)s in wild vegetables from mining areas: Implication for human oral health.

Background

Methods

Results

Conclusion

Publications

The oral bioaccessibility and gingival cytotoxicity of metal(loid)s in wild vegetables from mining areas: Implication for human oral health.

Similar Datasets

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