Correlating electroconvulsive therapy response to electroencephalographic markers: Study protocol.

ABSTRACT:

Introduction

Electroconvulsive therapy (ECT) is an effective intervention for patients with major depressive disorder (MDD). Despite longstanding use, the underlying mechanisms of ECT are unknown, and there are no objective prognostic biomarkers that are routinely used for ECT response. Two electroencephalographic (EEG) markers, sleep slow waves and sleep spindles, could address these needs. Both sleep microstructure EEG markers are associated with synaptic plasticity, implicated in memory consolidation, and have reduced expression in depressed individuals. We hypothesize that ECT alleviates depression through enhanced expression of sleep slow waves and sleep spindles, thereby facilitating synaptic reconfiguration in pathologic neural circuits.

Methods

Correlating ECT Respon

SUBMITTER: Subramanian S 

PROVIDER: S-EPMC9670172 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature