No evidence for an effect of selective spatial attention on the development of secondary hyperalgesia: A replication study.

ABSTRACT: Central sensitization refers to the increased responsiveness of nociceptive neurons in the central nervous system after repeated or sustained peripheral nociceptor activation. It is hypothesized to play a key role in the development of chronic pain. A hallmark of central sensitization is an increased sensitivity to noxious mechanical stimuli extending beyond the injured location, known as secondary hyperalgesia. For its ability to modulate the transmission and the processing of nociceptive inputs, attention could constitute a promising target to prevent central sensitization and the development of chronic pain. It was recently shown that the experimental induction of central sensitization at both forearms of healthy volunteers using bilateral high-frequency electrocutaneous stimulation (HF

SUBMITTER: Della Porta D 

PROVIDER: S-EPMC9670179 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature