The impact of prevention-effective PrEP use on HIV incidence: a mathematical modelling study.

ABSTRACT:

Introduction

Models that project the impact and cost-effectiveness of HIV pre-exposure prophylaxis (PrEP) must specify how PrEP use aligns with HIV exposure. We hypothesized that varying PrEP use according to individual-level partnership dynamics rather than prioritization to population subgroups based on average risk will result in larger incidence reductions and greater efficiency.

Methods

We used an individual-based network transmission model calibrated to HIV dynamics in Eswatini to simulate PrEP use among individuals ages 15-34 between 2022 and 2031 under two paradigms of PrEP delivery: "Risk Group" and "Partnership." In the "Risk Group" paradigm, we varied PrEP coverage by risk groups (low, medium and high) defined by average partnership frequency and concurrency. In t

SUBMITTER: Roberts DA 

PROVIDER: S-EPMC9670193 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature