Multiple-Streams Focusing-Based Cell Separation in High Viscoelasticity Flow.

ABSTRACT: Viscoelastic flow has been widely used in microfluidic particle separation processes, in which particles get focused on the channel center in diluted viscoelastic flow. In this paper, the transition from single-stream focusing to multiple-streams focusing (MSF) in high viscoelastic flow is observed, which is applied for cell separation processes. Particle focusing stream bifurcation is caused by the balance between elastic force and viscoelastic secondary flow drag force. The influence of cell physical properties, such as cell dimension, shape, and deformability, on the formation of multiple-streams focusing is studied in detail. Particle separation is realized utilizing different separation criteria. The size-based separation of red (RBC) and white (WBC) blood cells is demonstrated in whi

SUBMITTER: Feng H 

PROVIDER: S-EPMC9670260 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature