How do trial teams plan for retention during the design stage of the trial? A scoping review protocol.

ABSTRACT:

Background

Retention remains a major challenge for many clinical trials. The SPIRIT guidelines state the following information on retention should be included in the trial protocol "Plans to promote participant retention and complete follow-up, including list of any outcome data to be collected for participants who discontinue or deviate from intervention protocols". This guidance shows the importance of planning retention methods and handling missing data as this can impact how the results of the trial are interpreted. The most recent Cochrane review of strategies to improve retention in clinical trials highlighted that some trials implemented multiple retention strategies and we questioned whether the use of multiple strategies was planned at the design stage and included in the

SUBMITTER: Murphy E 

PROVIDER: S-EPMC9670576 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature