Pharmacodynamic mechanisms behind a refractory state in inflammatory bowel disease.

ABSTRACT:

Background and aims

Biological therapy for inflammatory bowel disease is efficient in many cases but not all. The underlying molecular mechanisms behind non-response to biological therapy in inflammatory bowel disease are poorly described. Therefore, we aimed to characterize the mucosal cytokine transcript profile in non-immunogenic, non-responder patients with adequate trough level.

Material and methods

Patients with ulcerative colitis (UC) (n = 21) and Crohn's disease (CD) (n = 12) with non-response to biological therapy (anti-tumor necrosis factor (TNF) or vedolizumab) were included. Reference groups were A: untreated patients with UC or CD at debut of disease who had severe 1-year outcome, B: patients with UC or CD treated to endoscopic remission with biological agents,

SUBMITTER: Goll R 

PROVIDER: S-EPMC9670620 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature