Accrual of organ damage in Behcet's syndrome: trajectory, associated factors, and impact on patients' quality of life over a 2-year prospective follow-up study.

ABSTRACT:

Background

This study aimed to investigate the trajectory of damage accrual, associated factors, and impact on health-related quality of life (HR-QoL) in a multicenter cohort of patients with Behçet's syndrome (BS) over 2 years of follow-up.

Methods

Patients recruited in the BS Overall Damage Index (BODI) validation study were prospectively monitored for 2 years and assessed for damage accrual, defined as an increase ≥1 in the BODI score, and HR-QoL was evaluated by the SF-36 questionnaire. Logistic and multiple linear regression models were built to determine factors associated with damage accrual and impairment in the different SF-36 domains.

Results

During follow-up, 36 out of 189 (19.0%) patients had an increase ≥1 in the BODI score with a mean (SD) difference of

SUBMITTER: Floris A 

PROVIDER: S-EPMC9670626 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature