Examining how and why polygenic dopamine composite levels moderate adolescents' vulnerability to peer victimization.

ABSTRACT: Extensive literature documents that dopaminergic genes play an important role in the link between adverse environments and adolescents' problem behavior. However, little is known about the potential mechanism underlying adolescents' vulnerability to peer victimization. The current study examined the effect of the interplay between a polygenic dopamine composite (i.e., COMT Val158Met and DRD2-141C Ins/Del polymorphisms) and peer victimization on adolescents' externalizing problems as well as the mediating role of emotion dysregulation in the interactive effects in a sample of 393 Chinese adolescents (Mean age = 14.71 years; 50.1% girls). A significant moderation of dopaminergic genetic composite was observed in girls but not in boys. In addition, emotion dysregulation partially explained th

SUBMITTER: Gao Y 

PROVIDER: S-EPMC9670640 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature