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Chemodivergent Synthesis of Aza-Heterocycles with a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes and α-Bromo Carbonyl Compounds.

ABSTRACT: An efficient [4 + 1] annulation reaction between in situ generated azoalkene intermediates and α-bromocarbonyls has been established. A series of skeletally diverse aza-heterocycles with a functionalized quaternary center were obtained in up to 89% yield under mild conditions.

SUBMITTER: Zhang X

PROVIDER: S-EPMC9670695 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Chemodivergent Synthesis of Aza-Heterocycles with a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes and α-Bromo Carbonyl Compounds.

Zhang Xiaoke X Wang Haibo H Li Ziwei Z Shu Yan Y Gan Song S Zhang Xuefang X Shao Huawu H Wang Chaoyong C

ACS omega 20221101 45

An efficient [4 + 1] annulation reaction between in situ generated azoalkene intermediates and α-bromocarbonyls has been established. A series of skeletally diverse aza-heterocycles with a functionalized quaternary center were obtained in up to 89% yield under mild conditions. ...[more]

PMID: 36406503

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