Oral Administration of Oxytocin, Like Intranasal Administration, Decreases Top-Down Social Attention.

ABSTRACT:

Background

The neuropeptide oxytocin (OXT) modulates social cognition by increasing attention to social cues and may have therapeutic potential for impaired social attention in conditions such as autism spectrum disorder. Intranasal administration of OXT is widely used to examine the drug's functional effects in both adults and children and is assumed to enter the brain directly via this route. However, OXT can also influence brain function through increased blood concentrations, and we have recently shown that orally (lingual) administered OXT also modulates neural responses to emotional faces and may be better tolerated for therapeutic use. Here, we examine whether 24 IU OXT administered orally can facilitate social attention.

Methods

In a randomized, placebo-controlled ph

SUBMITTER: Zhuang Q 

PROVIDER: S-EPMC9670742 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature