Miconazole Promotes Cooperative Ability of a Mouse Model of Alzheimer Disease.

ABSTRACT:

Background

Cooperative defect is 1 of the earliest manifestations of disease patients with Alzheimer disease (AD) exhibit, but the underlying mechanism remains unclear.

Methods

We evaluated the cooperative function of APP/PS1 transgenic AD model mice at ages 2, 5, and 8 months by using a cooperative drinking task. We examined neuropathologic changes in the medial prefrontal cortex (mPFC). Another experiment was designed to observe whether miconazole, which has a repairing effect on myelin sheath, could promote the cooperative ability of APP/PS1 mice in the early AD-like stage. We also investigated the protective effects of miconazole on cultured mouse cortical oligodendrocytes exposed to human amyloid β peptide (Aβ1-42).

Results

We observed an age-dependent impairment

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9670758 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature