Novel kinome profiling technology reveals drug treatment is patient and 2D/3D model dependent in glioblastoma.

ABSTRACT: Glioblastoma is the deadliest brain cancer. One of the main reasons for poor outcome resides in therapy resistance, which adds additional challenges in finding an effective treatment. Small protein kinase inhibitors are molecules that have become widely studied for cancer treatments, including glioblastoma. However, none of these drugs have demonstrated a therapeutic activity or brought more benefit compared to the current standard procedure in clinical trials. Hence, understanding the reasons of the limited efficacy and drug resistance is valuable to develop more effective strategies toward the future. To gain novel insights into the method of action and drug resistance in glioblastoma, we established in parallel two patient-derived glioblastoma 2D and 3D organotypic multicellular spheroi

SUBMITTER: Fabro F 

PROVIDER: S-EPMC9670801 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature