Cerebral neurovascular alterations in stable chronic obstructive pulmonary disease: a preliminary fMRI study.

ABSTRACT:

Purpose

Cognitive impairment (CI) is very common in patients with chronic obstructive pulmonary disease (COPD). Cerebral structural and functional abnormalities have been reported in cognitively impaired patients with COPD, and the neurovascular coupling changes are rarely investigated. To address this issue, arterial spin labeling (ASL) and resting-state blood oxygenation level dependent (BOLD) fMRI techniques were used to determine whether any neurovascular changes in COPD patients.

Methods

Forty-five stable COPD patients and forty gender- and age-matched healthy controls were recruited. Furthermore, resting-state BOLD fMRI and ASL were acquired to calculate degree centrality (DC) and cerebral blood flow (CBF) respectively. The CBF-DC coupling and CBF/DC ratio were compare

SUBMITTER: Peng Z 

PROVIDER: S-EPMC9671032 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature