Zonal Intratumoral Delivery of Nanoparticles Guided by Surface Functionalization.

ABSTRACT: Delivery of small molecules and anticancer agents to malignant cells or specific regions within a tumor is limited by penetration depth and poor spatial drug distribution, hindering anticancer efficacy. Herein, we demonstrate control over gold nanoparticle (GNP) penetration and spatial distribution across solid tumors by administering GNPs with different surface chemistries at a constant injection rate via syringe pump. A key finding in this study is the discovery of different zone-specific accumulation patterns of intratumorally injected nanoparticles dependent on surface functionalization. Computed tomography (CT) imaging performed in vivo of C57BL/6 mice harboring Lewis lung carcinoma (LLC) tumors on their flank and gross visualization of excised tumors consistently revealed that intrat

SUBMITTER: Terracciano R 

PROVIDER: S-EPMC9671122 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature