The radical scavenging activity of glycozolidol in physiological environments: a quantum chemical study.

ABSTRACT: Glycozolidol was isolated from the root of Glycosmis pentaphylla (6-hydroxy-2-methoxy-3-methylcarbazole, GLD). This molecule attracted considerable interest due to its beneficial biological activities that likely stem from its antioxidant activity; yet, the radical scavenging action of GLD has not been investigated thus far. In this study, DFT calculations were used to estimate the radical scavenging activity of GLD against a variety of biologically significant radical species in physiological environments. The findings demonstrated that GLD exerts significant antiradical activity in water at pH = 7.40 and in pentyl ethanoate (as a model of lipidic media) with k _overall = 8.23 × 10⁶ and 3.53 × 10⁴ M^-1 s^-1, respectively. I

SUBMITTER: Hieu LT 

PROVIDER: S-EPMC9671143 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature