Vascular biomechanics and molecular disease activity in the thoracic aorta: a novel imaging method.

ABSTRACT:

Aims

The influence haemodynamics have on vessel wall pathobiology in aortic disease is incomplete. This aim of this study was to develop a repeatable method for assessing the relationship between aortic wall shear stress (WSS) and disease activity by fusing 4D flow cardiovascular magnetic resonance (CMR) with hybrid positron emission tomography (PET).

Methods and results

As part of an ongoing clinical trial, patients with bicuspid aortic valve (BAV) were prospectively imaged with both 18F-sodium fluoride (18F-NaF) PET, a marker of calcification activity, and 4D flow CMR. We developed novel software allowing accurate 3D co-registration and high-resolution comparison of aortic peak systolic WSS and 18F-NaF PET uptake (maximum tissue-to-background ratio). Intra-observer repeata

SUBMITTER: Minderhoud SCS 

PROVIDER: S-EPMC9671295 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature