Diabetes medications and associations with Covid-19 outcomes in the N3C database: A national retrospective cohort study.

ABSTRACT:

Background

While vaccination is the most important way to combat the SARS-CoV-2 pandemic, there may still be a need for early outpatient treatment that is safe, inexpensive, and currently widely available in parts of the world that do not have access to the vaccine. There are in-silico, in-vitro, and in-tissue data suggesting that metformin inhibits the viral life cycle, as well as observational data suggesting that metformin use before infection with SARS-CoV2 is associated with less severe COVID-19. Previous observational analyses from single-center cohorts have been limited by size.

Methods

Conducted a retrospective cohort analysis in adults with type 2 diabetes (T2DM) for associations between metformin use and COVID-19 outcomes with an active comparator design of prevale

SUBMITTER: Bramante CT 

PROVIDER: S-EPMC9671347 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature