Consequences of exposure to pollutants on respiratory health: From genetic correlations to causal relationships.

ABSTRACT: Modern society grew rapidly over the last few decades and this led to an alarming increase in air pollutants and a worsening of the human health, especially in relation to the respiratory system. Indeed, chronic respiratory diseases were the third main cause of death in 2017, with over 3 million of deaths. Furthermore, the pollution has considerable consequences both for burden medical expenses and environmental. However, the mechanisms linking pollutants to the onset of these diseases remain unclear. Thus, in this study we addressed this problem through the United Kingdom BioBank database, analyzing 170 genome-wide association studies (103 related to respiratory diseases and 67 related to pollutants). We analyzed the genetic correlations and causal relationships of these traits, leveragin

SUBMITTER: D'Antona S 

PROVIDER: S-EPMC9671383 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature