Childhood exposures to environmental chemicals and neurodevelopmental outcomes in congenital heart disease.

ABSTRACT:

Background

Children with congenital heart defects have an increased risk of neurodevelopmental disability. The impact of environmental chemical exposures during daily life on neurodevelopmental outcomes in toddlers with congenital heart defects is unknown.

Methods

This prospective study investigated the impacts of early childhood exposure to mixtures of environmental chemicals on neurodevelopmental outcomes after cardiac surgery. Outcomes were assessed at 18 months of age using The Bayley Scales of Infant and Toddler Development-III. Urinary concentrations of exposure biomarkers of pesticides, phenols, parabens, and phthalates, and blood levels of lead, mercury, and nicotine were measured at the same time point. Bayesian profile regression and weighted quantile sum regressio

SUBMITTER: Gaynor JW 

PROVIDER: S-EPMC9671412 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature