Outcomes of Primary Simultaneous Pancreas-kidney Transplants by Induction Agent in the United States.

ABSTRACT: Long-term outcome data by induction type in simultaneous pancreas-kidney (SPK) is limited.

Methods

Utilizing the Scientific Registry of Transplant Recipients, we examined all primary SPK transplants between 2000 and 2020, excluding crossmatch-positive recipients. We grouped recipients according to induction regimen into 3 groups: rabbit anti-thymocyte globulin (r-ATG) (n = 5678), alemtuzumab (n = 1199), and interleukin-2 receptor antagonist (IL-2RA; n = 1593). We analyzed the 10-y recipient and composite (kidney and pancreas) graft survival using the Kaplan-Meier survival function. Cox-proportion hazard models were generated to examine the association between induction type, the 10-y recipient, and graft survival. Models were adjusted for recipient age, sex, ethnicity, HLA-mismatch,

SUBMITTER: Cerise A 

PROVIDER: S-EPMC9671748 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature