Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation.

ABSTRACT: Despite nearly a century of clinical use as a blood thinner, heparin's rapid serum clearance and potential to induce severe bleeding events continue to urge the development of more effective controlled delivery strategies. Subcutaneous depots that steadily release the anticoagulant into circulation represent a promising approach to reducing overdose frequency, sustaining therapeutic concentrations of heparin in plasma, and prolonging anticoagulant activity in a safe and effective manner. Subcutaneously deliverable heparin-peptide nanogranules that allow for long-lasting heparin bioavailability in the circulatory system, while enabling on-demand activation of heparin's anticoagulant effects in the thrombus microenvironment, are reported. Biophysical studies demonstrate this responsive behav

SUBMITTER: Lawanprasert A 

PROVIDER: S-EPMC9671832 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature