The role of astrocytes in place cell formation: A computational modeling study.

ABSTRACT: Place cells develop spatially-tuned receptive fields during the early stages of novel environment exploration. The generative mechanism underlying these spatially-selective responses remains largely elusive, but has been associated with theta rhythmicity. An important factor implicating the transformation of silent cells to place cells is a spatially-uniform depolarization that is mediated by a persistent sodium current. This neuronal current is modulated by extracellular calcium concentration, which, in turn, is actively controlled by astrocytes. However, there is no established relationship between the neuronal depolarization and astrocytic activity. To consider this link, we designed a bioplausible computational model of a neuronal-astrocytic network, where astrocytes induced the transi

SUBMITTER: Polykretis I 

PROVIDER: S-EPMC9671849 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature