Risk factors and prognostic significance of anemia in children with HIV infection on antiretroviral therapy.

ABSTRACT:

Objectives

To establish the incidence, risk factors and prognostic effect of anemia in children living with HIV (CLWH).

Design

Retrospective nested case-control study of patients 0-18 years in five centers in sub-Saharan Africa, 2004-2014.

Methods

Incident cases of anemia were identified from electronic records and matched with CLWH without anemia. We calculated the incidence density of anemia and used conditional logistic regression to evaluate its association with risk factors, stratified by severity and type of anemia. We used a Cox proportional hazards model to evaluate the impact of anemia on survival.

Results

Two thousand, one hundred and thirty-seven children were sampled. The incidence density of anemia was 1 per 6.6 CLWH-years. Anemia was moderate in 3

SUBMITTER: Lubega J 

PROVIDER: S-EPMC9671853 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature