Cell-type-specific integration of feedforward and feedback synaptic inputs in the posterior parietal cortex.

ABSTRACT: The integration of feedforward (sensory) and feedback (top-down) neuronal signals is a principal function of the neocortex. Yet, we have limited insight into how these information streams are combined by individual neurons. Using a two-color optogenetic strategy, we found that layer 5 pyramidal neurons in the posterior parietal cortex receive monosynaptic dual innervation, combining sensory inputs with top-down signals. Subclasses of layer 5 pyramidal neurons integrated these synapses with distinct temporal dynamics. Specifically, regular spiking cells exhibited supralinear enhancement of delayed-but not coincident-inputs, while intrinsic burst-firing neurons selectively boosted coincident synaptic events. These subthreshold integration characteristics translated to a nonlinear summation o

SUBMITTER: Rindner DJ 

PROVIDER: S-EPMC9671855 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature