Uptake of Plasmodium chabaudi hemozoin drives Kupffer cell death and fuels superinfections.

ABSTRACT: Kupffer cells (KCs) are self-maintained tissue-resident macrophages that line liver sinusoids and play an important role on host defense. It has been demonstrated that upon infection or intense liver inflammation, KCs might be severely depleted and replaced by immature monocytic cells; however, the mechanisms of cell death and the alterations on liver immunity against infections deserves further investigation. We explored the impact of acute Plasmodium infection on KC biology and on the hepatic immune response against secondary infections. Similar to patients, infection with Plasmodium chabaudi induced acute liver damage as determined by serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) elevation. This was associated with accumulation of hemozoin, increased of proin

SUBMITTER: Hirako IC 

PROVIDER: S-EPMC9671901 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature