Ontology highlight
ABSTRACT:
SUBMITTER: Bostrom M
PROVIDER: S-EPMC9671924 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Boström Martin M Larsson Erik E
Nature communications 20221117 1
Cancer gene discovery is reliant on distinguishing driver mutations from a multitude of passenger mutations in tumour genomes. While driver genes may be revealed based on excess mutation recurrence or clustering, there is a need for orthogonal principles. Here, we take advantage of the fact that non-cancer genes, containing only passenger mutations under neutral selection, exhibit a likelihood of mutagenesis in a given tumour determined by the tumour's mutational signature and burden. This relat ...[more]