Dataset Information

Diet consistency modification improves postprandial glycemic and gastroparesis symptoms.

ABSTRACT:

Abstract

Diabetic gastroparesis (DGP) is an autonomic neuropathy resulting from long-standing poorly controlled diabetes, and it is also linked to fluctuations in glycemic control due to variability on nutrient absorption.

Objectives

Considering the scarcity of information, the aim of this study was to identify the impact of modifications on diet consistency on post-prandial glucose variability using a continuous glucose monitoring (CGM) and its effect on the perception and severity of gastrointestinal symptoms.

Methods

This proof-of-concept study was carried out in a cross-sectional cohort of six individuals with type 1 diabetes mellitus with confirmed diagnosis of DGP. Two types of diet were used to evaluate glycemic control and DGP symptoms, general consistency standard meal (SD) and modified consistency test diet (MD), associated with an application of rapid acting insulin at the time of food intake. Glycemic control was evaluated by CGM, and the Gastroparesis Cardinal Symptom Index (GCSI) was applied after meals.

Results

The CGM curve was different for MD + insulin and SD + insulin. There was a smaller increment of interstitial glucose with 2 h after MD + insulin, returning almost to the basal level 4 h later. Patients scored significantly lower GCSI after MD + insulin compared to the same index after they received SD + insulin. Moreover, there was a decrease in important clinical scores present in the index, like: "Not able to finish meal", "Loss of appetite" and "Stomach or belly feels larger".

Conclusion

This study showed that a modified diet can improve postprandial glycemic excursion and the perception and severity of gastroparesis symptoms.

Supplementary information

The online version contains supplementary material available at 10.1007/s40200-022-01117-w.

SUBMITTER: Betonico CC

PROVIDER: S-EPMC9672186 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

Diet consistency modification improves postprandial glycemic and gastroparesis symptoms.

Betônico Carolina C CC Cobello Aline Vial AV Santos-Bezerra Daniele P DP de A Leite André Z AZ Correa-Giannella Maria Lúcia ML Nery Márcia M Queiroz Márcia S MS

Journal of diabetes and metabolic disorders 20220919 2

<h4>Abstract</h4>Diabetic gastroparesis (DGP) is an autonomic neuropathy resulting from long-standing poorly controlled diabetes, and it is also linked to fluctuations in glycemic control due to variability on nutrient absorption.<h4>Objectives</h4>Considering the scarcity of information, the aim of this study was to identify the impact of modifications on diet consistency on post-prandial glucose variability using a continuous glucose monitoring (CGM) and its effect on the perception and severi ...[more]

PMID: 36404814

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Dataset Information

Diet consistency modification improves postprandial glycemic and gastroparesis symptoms.

Abstract

Objectives

Methods

Results

Conclusion

Supplementary information

Publications

Diet consistency modification improves postprandial glycemic and gastroparesis symptoms.

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