Relationship between a near Melanocortin-4 receptor gene variant and puberty timing in children is vague unlike obesity.

ABSTRACT:

Background

Obesity is a complicated phenomenon which is a combination of genetic, environmental, and psychological factors. Genetic factors of obesity play an important role in individual risk. It is well known that obese children have disturbed puberty timing. To the best of our knowledge, no study has been performed to investigate the association between MC4R gene mutation and puberty timing.

Methods

This study was performed as a cross-sectional study evaluating the near MC4R rs17782313 variation in 60 obese children and 98 healthy non obese children. Weight, height, BMI ( Body Mass Index ), BMI z-score (BMIz), family history of diabetes mellitus and obesity, the age of the obesity onset, overeating behavior, type of obesity (central or general) and puberty stage were eval

SUBMITTER: Mohsenipour R 

PROVIDER: S-EPMC9672209 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature