Validation of dynamic [¹⁸F]FE-PE2I PET for estimation of relative regional cerebral blood flow: a comparison with [¹⁵O]H₂O PET.

ABSTRACT:

Background

Dopamine transporter (DAT) imaging is used in the diagnostic work-up in suspected parkinsonian syndromes and dementia with Lewy bodies but cannot differentiate between these syndromes, and an extra brain imaging examination of the regional cerebral blood flow (rCBF) or glucose metabolism is often needed for differential diagnosis. The requirement of two different imaging examinations is resource-consuming and inconvenient for the patients. Therefore, imaging of both cortical blood flow and DAT imaging with the same radiotracer would be more convenient and cost-effective. The aim of this study was to test whether relative regional cerebral blood flow (rCBF_R) can be measured with the DAT-specific positron emission tomography (PET) tracer [¹⁸F]FE-PE2I

SUBMITTER: Jakobson Mo S 

PROVIDER: S-EPMC9672223 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature