A comparative meta-analysis of membraneless organelle-associated proteins with age related proteome of C. elegans.

ABSTRACT: Proteome imbalance can lead to protein misfolding and aggregation which is associated with pathologies. Protein aggregation can also be an active, organized process and can be exploited by cells as a survival strategy. In adverse conditions, it is beneficial to deposit the proteins in a condensate rather degrading and resynthesizing. Membraneless organelles (MLOs) are biological condensates formed through liquid-liquid phase separation (LLPS), involving cellular components such as nucleic acids and proteins. LLPS is a regulated process, which when perturbed, can undergo a transition from a physiological liquid condensate to pathological solid-like protein aggregates. To understand how the MLO-associated proteins (MLO-APs) behave during aging, we performed a comparative meta-analysis with a

SUBMITTER: Mukherjee P 

PROVIDER: S-EPMC9672229 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature