Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior.

ABSTRACT: Observational studies of long-term users of ayahuasca, an Amazonian psychedelic brew, suggest an increase in resilience via improvements in emotion and cognition. Ayahuasca has also demonstrated clinical antidepressant effects in human and animal studies; however, its potential prophylactic action in depression has not been previously studied. Therefore, this experimental study sought to evaluate the potential prophylactic effects of repeated and long-term ayahuasca use, via the modulation of resilience, in a non-human primate animal model, Callithrix jacchus, subjected to a protocol for induction of depressive-like behavior. For the formation of the study groups, some juvenile marmosets were kept in their family groups (GF = 7), while for the two experimental groups,

SUBMITTER: de Meiroz Grilo MLP 

PROVIDER: S-EPMC9672345 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature