METTL16 regulates m⁶A methylation on chronic hepatitis B associated gene HLA-DPB1 involved in liver fibrosis.

ABSTRACT: The role of genetic factors in the occurrence and progression of CHB (CHB) is still not fully explored. In recent years, genome-wide association studies on CHB patients have demonstrated that a large number of CHB-associated single nucleotide polymorphisms exist in the gene intron, which may regulate expression at the transcriptional level. Modification of RNA m⁶A methylation is one of the key mechanisms regulating gene expression. Here we show that METTL16, an m⁶A regulator involved in mRNA intron splicing, is differentially expressed in CHB the tissue of patients who has definite diagnosis of mild and severe fibrosis. At the same time, there are also significant differences in the expression of CHB-associated genes such as HLA-DPA1 and HLA-DPB1.

SUBMITTER: Gao H 

PROVIDER: S-EPMC9672369 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature